Selected Publications
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Amar M#, Pramod AB#, Yu N-K, Herrera VM, Qiu LR, Moran-Losada P, Zhang, Trujillo CA, Ellegood, J, Urresti J, Chau K, Diedrich J, Chen J, Gutierrez J, Sebat J,
Ramanathan D, Lerch JP, Yates III JR, Muotri AR*, Iakoucheva LM*.
Jiang Y,Urressti J, Pagel KA, Pramod AB,Iakoucheva LM,Radivojac P*.
Chau K, Zhang P, Urressti J, Amar M, Pramod AB, Chen J, Thomas A, Corominas R, Lin GN,Iakoucheva LM*.
Urresti J#, Zhang P#, Moran-Losada P, Yu N-K, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates III JR, Muotri AR*, Iakoucheva LM*.
Pejaver V, Urresti J, Lugo-Martinez J, Pagel KA, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P.
Qiu Y, Arbogast T, Lorenzo SM, Li H, Tang SC, Richardson E, Hong O, Cho S, Shanta O, Pang T, Corsello C, Deutsch CK, Chevalier C, Davis EE, Iakoucheva LM, Herault Y, Katsanis N, Messer K, Sebat J.
Iakoucheva LM, Muotri AR, Sebat J.
Pagel KA, Antaki D, Lian A, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P.
Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C*, Iakoucheva LM*, Pinto D*, Geschwind DH*.
Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J.
Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P.
Lin GN, Corominas R, Nam HJ, Urresti J, Iakoucheva LM.
Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J*.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM*, Xia Y*, Vidal M*.
Lin GN*, Corominas R*, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM.
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian S, Yang X, Ghamsari L,
Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis A-R, Convery-Zupan D, Corominas R, Hardy M, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C,
Franzosa E, Gebreab F, Gutierrez BJ, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J,
Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere J, Vega K, Walsh J,
Cusick ME, Xia Y, Barabasi A-L, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M.
Uversky VN, Vrushank Davé, Iakoucheva LM, Malaney P, Metallo SJ, Pathak RR, Joerger AC.
Corominas R*, Yang X*, Lin GN*, Kang S*, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM.
Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA.Dembinski H1, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA.
Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J.
Vacic V, Markwick P, Oldfield CJ, Zhao X, Haynes C, Uversky V, Iakoucheva LM.
Vacic V, Iakoucheva LM.
Vacic V, … Corominas R, Iakoucheva LM…[30 authors], Sebat J.
Mills R, … Iakoucheva LM…[57 authors], Korbel J.
Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
Vacic V, Iakoucheva LM, Lonardi S, Radivojac P.
Li S, Iakoucheva LM, Mooney SD, Radivojac P.
McCarthy SE, … Iakoucheva LM…[71 authors], Sebat J.
Boxem M, … Iakoucheva LM… [36 authors], Vidal M.
Haynes C, Oldfield CJ, Ji F, Klitgord N, Cusick ME, Radivojac P, Uversky VN, Vidal M, Iakoucheva LM.
Haynes C, Iakoucheva LM.
Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK.
Iakoucheva LM, Brown CJ, Lawson JD, Obradović Z, Dunker AK.
Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM, Obradović Z.
(# equal contribution)
(* Co-corresponding authors)
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling..
Molecular Psychiatry. 2021, in press.[PDF]
(* Corresponding authors)
Prioritizing autism risk variants with calibrated gene- and variant-specific models..
Bioinformatics, 2021, under review.[PDF]
(* Corresponding authors)
Full-length isoform transcriptome of developing human brain provides new insights into autism..
Cell Reports. 2021, under review.[PDF]
(# equal contribution)
(* Co-corresponding authors)
Development Disrupted by 16p11.2 Copy Number Variants in Autism..
Molecular Psychiatry. 2021, under review.[PDF]
Inferring the molecular and phenotypic impact of amino acid variants with MutPred2..
Nat Commun. 2020 Nov 20;11(1):5918. doi: 10.1038/s41467-020-19669-x. PMID: 33219223.[PDF]
Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development..
Cell Reports. 2019 Sep 24;28(13):3320-3328.e4. doi: 10.1016/j.celrep.2019.08.071. PMID: 31553903.[PDF]
Getting to the Cores of Autism..
Cell. 2019 Sep 5;178(6):1287-1298. doi: 10.1016/j.cell.2019.07.037.PMID: 31491383. Review.[PDF]
Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome..
PLoS Comput Biol. 2019 Jun 14;15(6):e1007112. doi: 10.1371/journal.pcbi.1007112. eCollection 2019 Jun. PMID: 31199787.[PDF]
(* Co-corresponding authors)
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder..
Science. 2018 Dec 14;362(6420).pii: eaat8127. doi: 10.1126/science.aat8127.[PDF]
(Featured by STAT media,
UCSD)
Paternally inherited cis-regulatory structural variants are associated with autism..
Science. 2018 Apr 20;360(6386):327-331. doi: 10.1126/science.aan2261.[PDF]
When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants..
Bioinformatics. 2017 Jul 15;33(14):i389-i398. doi: 10.1093/bioinformatics/btx272.[PDF]
Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases.
Methods Mol Biol. 2017 2017;1613:371-402. doi: 10.1007/978-1-4939-7027-8_15.[PDF]
Frequency and Complexity of De Novo Structural Mutation in Autism.
Am J Hum Genet. 2016 Apr 7;98(4):667-79. doi: 10.1016/j.ajhg.2016.02.018. [PDF]
(* Corresponding authors)
(Featured by SFARI
)
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell. 2016 Feb 11;164(4):805-17. doi: 10.1016/j.cell.2016.01.029. [PDF]
(* Co-corresponding authors)
(Featured by UCSD,
The Scientist,
Science Daily,
Science Newsline Medicine,
Nature Methods|Research Highlights
)
Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases.
Neuron. 2015 Feb 18;85(4):742-54. doi: 10.1016/j.neuron.2015.01.010. (Issue Highlights). [Goggle scholar] [PDF]
(* Co-first authors)
(Featured by Scientific American Mind,
UCSD,
SFARI,
IFLScience,
ScienceDaily,
Medical Xpress,
San Diego County News,
ANI News,
MedIndia,
Sci Guru Science News,
Neuroscience news,
Business 2 community, etc)
A proteome-scale map of the human interactome network.
Cell. 2014 Nov 20;159(5):1212-26. [Goggle scholar] [PDF]
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.
Chem Rev. 2014 Jul 9;114(13):6844-79. doi: 10.1021/cr400713r. Epub 2014 May 15. [Goggle scholar] [PDF]
Protein interaction network of alternativelyspliced isoforms from brain links genetic risk factors for autism.
Nat. Commun. 2014 April 11;5:3650 doi: 10.1038/ncomms4650. [Goggle scholar] [PDF]
(* Equal contribution)
(Featured by UCSD,
SFARI,
Nature Commu, ScienceDaily,
neurosciencenews, newswise)
Predicted disorder-to-order transition mutations in IκBα disrupt function.
Phys Chem Chem Phys. 2014 Apr 14;16(14):6480-5. doi: 10.1039/c3cp54427c. Epub 2014 Mar 6. [Goggle scholar] [PDF]
Whole-genome sequencing in autism identifies hot spots for de novo germline mutation.
Cell. 2012 Dec 21;151(7):1431-42. [Goggle scholar] [PDF]
Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder.
PLoS Comput Biol. 2012;8(10):e1002709. doi: 10.1371/journal.pcbi.1002709. Epub 2012 Oct 4. [Goggle scholar] [PDF]
Disease mutations in disordered regions--exception to the rule?
Mol. BioSyst. 2012 Jan;8(1):27-32. doi: 10.1039/c1mb05251a. Epub 2011 Nov 14. [Goggle scholar] [PDF]
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
Nature. 2011 Mar 24;471(7339):499-503. doi: 10.1038/nature09884. Epub 2011 Feb 23. [Goggle scholar] [PDF]
Mapping copy number variation by population-scale genome sequencing
Nature. 2011 Feb 3;470(7332):59-65. doi: 10.1038/nature09708. [Goggle scholar] [PDF]
Identification, analysis, and prediction of protein ubiquitination sites.
Proteins. 2010 Feb 1;78(2):365-80. doi: 10.1002/prot.22555. [Goggle scholar] [PDF]
Graphlet kernels for prediction of functional residues in protein structures.
J Comput Biol. 2010 Jan;17(1):55-72. doi: 10.1089/cmb.2009.0029. [Goggle scholar] [PDF]
Loss of post-translational modification sites in disease.
Pac Symp Biocomput. 2010:337-47. [Goggle scholar] [PDF]
Microduplications of 16p11.2 are associated with schizophrenia.
Nat Genet. 2009 Nov;41(11):1223-7. doi: 10.1038/ng.474. Epub 2009 Oct 25. [Goggle scholar] [PDF]
A protein domain-based interactome network for C. elegans early embryogenesis.
Cell. Aug 8;134(3):534-45. doi: 10.1016/j.cell.2008.07.009. [Goggle scholar] [PDF]
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes.
PLoS Comput Biol. 2006 Aug 4;2(8):e100. Epub 2006 Jun 23. [Goggle scholar] [PDF]
Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins.
Nucleic Acids Res. 2006 Jan 10;34(1):305-12. Print 2006. [Goggle scholar] [PDF]
The importance of intrinsic disorder for protein phosphorylation.
Nucleic Acids Res. 2004 Feb 11;32(3):1037-49. Print 2004. [Goggle scholar] [PDF]
Intrinsic disorder in cell-signaling and cancer-associated proteins.
J Mol Biol. 2002 Oct 25;323(3):573-84. [Goggle scholar] [PDF]
Intrinsic disorder and protein function.
Biochemistry. 2002 May 28;41(21):6573-82. [Goggle scholar] [PDF]